3,4-Difluorobenzonitrile → HCID 74221583, compound

HRID 2408579Notes

Reaction equation

HRID 2408579 reaction equation
C[O:2][C:3](=[O:26])[CH2:4][C@H:5]1[C:9]2[CH:10]=[CH:11][C:12]([O:14][C@H:15]3[C:23]4[C:18](=[C:19]([OH:25])[CH:20]=[CH:21][C:22]=4[F:24])[CH2:17][CH2:16]3)=[CH:13][C:8]=2[O:7][CH2:6]1.[F:27][C:28]1[CH:29]=[C:30]([CH:33]=[CH:34][C:35]=1F)[C:31]#[N:32]>>[C:31]([C:30]1[CH:33]=[CH:34][C:35]([O:25][C:19]2[CH:20]=[CH:21][C:22]([F:24])=[C:23]3[C:18]=2[CH2:17][CH2:16][C@H:15]3[O:14][C:12]2[CH:11]=[CH:10][C:9]3[C@H:5]([CH2:4][C:3]([OH:26])=[O:2])[CH2:6][O:7][C:8]=3[CH:13]=2)=[C:28]([F:27])[CH:29]=1)#[N:32]

Participants

3

Reactant 2

HCID 5872033,4-DifluorobenzonitrileHCID 86720104[(S)-6-((R)-7-Fluoro-4-hydroxyindan-1-yloxy)-2,3-dihydrobenzofuran-3-yl]-acetic acid methyl ester

Product 1

HCID 74221583HCID 74221583, compound

Procedure

The methyl ester of the title compound is prepared from {(S)-6-[(R)-7-fluoro-4-hydroxy-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester and 3,4-difluoro-benzonitrile following a procedure analogous to that described for Intermediate 12. The title compound is obtained after saponification of the methyl ester as described for Example 1. LC (method 2): tR=1.11 min; Mass spectrum (ESI+): m/z=464 [M+H]+.

Sources & evidence

ORD record
ord-efc093361a2a40238ce679a6f96a644c
Source dataset
uspto-grants-2014_08
Patent number
US08815864B2

Reaction notes

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