1,4-Dioxane hydrochloride → HCID 67386428, compound

HRID 2408833Notes

Reaction equation

HRID 2408833 reaction equation
[CH2:1]([N:8]1[CH2:23][CH2:22][C:11]2([CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12]2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:24].O1CCOCC1>CO>[ClH:24].[ClH:24].[CH2:1]([N:8]1[CH2:9][CH2:10][C:11]2([CH2:14][NH:13][CH2:12]2)[CH2:22][CH2:23]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 45790087tert-Butyl 7-benzyl-2,7-diazaspiro[3.5]nonane-2-carboxylate

Product 1

HCID 67386428HCID 67386428, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of tert-butyl 7-benzyl-2,7-diazaspiro[3.5]nonane-2-carboxylate (CAS 929301-99-5 WO2007030061) in methanol was added 4 N HCl/dioxane. The mixture was stirred at room temperature for 2 hours. The reaction mixture was then concentrated to obtain the title compound. MS (DCI+) m/z 217 (M+H)+.

Workup

  1. concentrationThe reaction mixture was then concentrated

Sources & evidence

ORD record
ord-0931c84e8efb420395ec0559a98c4c80
Source dataset
uspto-grants-2014_08
Patent number
US08815869B2

Reaction notes

Loading…