反应详情

The product from Example 25C (0.95 g, 2.42 mmol) was dissolved in ethanol/water (4:1, 50 mL) and treated with lithium hydroxide (7.85 g, 328.0 mmol). After stirring for 3 hours at reflux, the reaction was concentrated, diluted with ice/water (50 mL) and neutralized with 1 N HCl. The resulting precipitate was collected by filtration, washed with water (50 mL) and air-dried to afford the title compound.

1. temperatureat reflux
2. concentrationthe reaction was concentrated
3. additiondiluted with ice/water (50 mL)
4. filtrationThe resulting precipitate was collected by filtration
5. washwashed with water (50 mL)
6. customair-dried