反应详情

温度

25 °C

Ethanol (29.3 ml) and water (0.74 ml) were added to 2-{4-amino-2-[(3-chloro-4-methoxy-5-methylpyridin-2-yl)methyl]-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-8-yl}-N-methylacetamide (1.034 g, 2.243 mmol), and the mixture was then stirred at 25° C. Thereafter, 2 M hydrochloric acid in ethanol (6.73 ml, 13.46 mmol) was added to the reaction mixture, and the resulting mixture was then stirred for 3 hours 45 minutes. Thereafter, the precipitated crystal was filtrated, was then washed with ethanol (5 ml), and was then dried under reduced pressure at 40° C. for 1 hour, so as to obtain the above title compound (1.118 g, 2.155 mmol). Yield: 96%.

1. stirringthe resulting mixture was then stirred for 3 hours 45 minutes
2. filtrationThereafter, the precipitated crystal was filtrated
3. washwas then washed with ethanol (5 ml)
4. customwas then dried under reduced pressure at 40° C. for 1 hour