Hydrochloric Acid → HCID 86691670, compound

Participants

Reaction Steps

3 M hydrochloric acid (369.6 mL) was added dropwise to an acetone (30 mL) suspension of 2-{4-amino-2-[(3-chloro-4-methoxy-5-methylpyridin-2-yl)methyl]-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-8-yl}-N-methylacetamide (493.48 mg, 1.11 mmol) at room temperature, while the suspension was stirred. The resulting mixture was further stirred for 12 hours. The obtained crystal was collected by filtration, was then washed with acetone, and was then dried under reduced pressure at 25° C. for 3 hours, so as to obtain the above title compound (531.01 mg, 1.02 mmol). Yield: 92%.

Provenance & Evidence