反应详情

3 M hydrochloric acid (369.6 mL) was added dropwise to an acetone (30 mL) suspension of 2-{4-amino-2-[(3-chloro-4-methoxy-5-methylpyridin-2-yl)methyl]-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-8-yl}-N-methylacetamide (493.48 mg, 1.11 mmol) at room temperature, while the suspension was stirred. The resulting mixture was further stirred for 12 hours. The obtained crystal was collected by filtration, was then washed with acetone, and was then dried under reduced pressure at 25° C. for 3 hours, so as to obtain the above title compound (531.01 mg, 1.02 mmol). Yield: 92%.

1. stirringThe resulting mixture was further stirred for 12 hours
2. filtrationThe obtained crystal was collected by filtration
3. washwas then washed with acetone
4. customwas then dried under reduced pressure at 25° C. for 3 hours