反应详情

3 M hydrochloric acid (0.527 ml, 1.58 mmol) was added dropwise to an ethanol (10.7 ml) suspension of 2-{4-amino-2-[(3-chloro-4-methoxy-5-methylpyridin-2-yl)methyl]-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-8-yl}-N-methylacetamide (306 mg, 0.686 mmol) at 25° C., while the suspension was stirred. The resulting mixture was stirred for 4 hours. The obtained crystal was collected by filtration, was then washed with ethanol (1.5 ml), and was then dried under reduced pressure at 40° C. for 1 hour, so as to obtain the above title compound (295 mg, 0.612 mmol). Yield: 89%.

1. stirringThe resulting mixture was stirred for 4 hours
2. filtrationThe obtained crystal was collected by filtration
3. washwas then washed with ethanol (1.5 ml)
4. customwas then dried under reduced pressure at 40° C. for 1 hour