反应详情

3 M hydrochloric acid (0.393 ml, 1.18 mmol) was added dropwise, divided over twice, to an ethanol (30 ml) suspension of 2-{4-amino-2-[(3-chloro-4-methoxy-5-methylpyridin-2-yl)methyl]-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-8-yl}-N-methylacetamide (527.5 mg, 1.18 mmol) at room temperature, while the suspension was stirred. Thereafter, the resulting mixture was stirred for 1 hour. The obtained crystal was collected by filtration, was then washed with ethanol (6 ml), and was then dried under reduced pressure at 40° C. for 30 minutes, so as to obtain the above title compound (525.3 mg, 1.09 mmol). Yield: 92%.

1. stirringThereafter, the resulting mixture was stirred for 1 hour
2. filtrationThe obtained crystal was collected by filtration
3. washwas then washed with ethanol (6 ml)
4. customwas then dried under reduced pressure at 40° C. for 30 minutes