HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 71073339 | HCID 71073339 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Hydrochloric Acid | HCID 313 | 99% |
| Product | HCID 71073366 | HCID 71073366 | — |
Reaction Steps
The Boc-protected amine 56-a (332 mg, 0.689 mmol) was added 4M HCl in 1,4-dioxane (5 mL) and the reaction was stirred for 20 min. The product was isolated by degassing the reaction (N2/vacuum cycles) followed by lyophilisation. This gave the title compound as the bis HCl salt (310 mg, >99%). ES+ 382.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815809B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-b008cc96fbb04063b19d0a311da4299f |
| Source note | uspto-grants-2014_08 |