Hydrochloric Acid → Hydrochloric Acid

HRID 2408935Notes

Reaction equation

HRID 2408935 reaction equation
C(OC(=O)[NH:7][CH:8]([C:16](=[O:33])[NH:17][C:18]1([CH:22]([OH:32])[C:23](=[O:31])[NH:24][C:25]2[CH:29]=[CH:28][N:27]([CH3:30])[N:26]=2)[CH2:21][CH2:20][CH2:19]1)[CH2:9][C:10]1([F:15])[CH2:14][CH2:13][CH2:12][CH2:11]1)(C)(C)C.[ClH:35]>O1CCOCC1>[NH2:7][CH:8]([CH2:9][C:10]1([F:15])[CH2:14][CH2:13][CH2:12][CH2:11]1)[C:16]([NH:17][C:18]1([CH:22]([OH:32])[C:23](=[O:31])[NH:24][C:25]2[CH:29]=[CH:28][N:27]([CH3:30])[N:26]=2)[CH2:21][CH2:20][CH2:19]1)=[O:33].[ClH:35]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 71073339HCID 71073339, compound

Product 2

HCID 313Hydrochloric AcidYield 99%HCID 71073366HCID 71073366, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The Boc-protected amine 56-a (332 mg, 0.689 mmol) was added 4M HCl in 1,4-dioxane (5 mL) and the reaction was stirred for 20 min. The product was isolated by degassing the reaction (N2/vacuum cycles) followed by lyophilisation. This gave the title compound as the bis HCl salt (310 mg, >99%). ES+ 382.1 [M+H]+.

Workup

  1. customThe product was isolated
  2. customby degassing
  3. customthe reaction (N2/vacuum cycles)

Sources & evidence

ORD record
ord-b008cc96fbb04063b19d0a311da4299f
Source dataset
uspto-grants-2014_08
Patent number
US08815809B2

Reaction notes

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