HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloropyrido[2,3-d]pyrimidine → 5-tert-Butyl-3-(pyridino[2,3-d]pyrimidin-4-ylamino)selenophene-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloropyrido[2,3-d]pyrimidine | HCID 569039 | — |
| Reactant | 3-Amino-5-tert-butylselenophene-2-carboxamide | HCID 86646889 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 5-tert-Butyl-3-(pyridino[2,3-d]pyrimidin-4-ylamino)selenophene-2-carboxamide | HCID 86698274 | — |
Reaction Steps
As shown in scheme G, 4-chloropyrido[2,3-d]pyrimidine (Robins, R. K. et. al., J. Am. Chem. Soc., 1955, 77, 2256-2260) is reacted with 5-tert-butyl-3-aminoselenophene-2-carboxamide in a protic solvent such as isopropyl alcohol to yield 5-(tert-butyl)-3-(pyridino[3,2-e]pyrimidin-4-ylamino)selenophene-2-carboxamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815879B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-4219537690a0490f8c6a6709a296dbd8 |
| Source note | uspto-grants-2014_08 |