4-Chloropyrido[2,3-d]pyrimidine → 5-tert-Butyl-3-(pyridino[2,3-d]pyrimidin-4-ylamino)selenophene-2-carboxamide

HRID 2408943Notes

Reaction equation

HRID 2408943 reaction equation
Cl[C:2]1[C:3]2[CH:11]=[CH:10][CH:9]=[N:8][C:4]=2[N:5]=[CH:6][N:7]=1.[C:12]([C:16]1[Se:20][C:19]([C:21]([NH2:23])=[O:22])=[C:18]([NH2:24])[CH:17]=1)([CH3:15])([CH3:14])[CH3:13]>C(O)(C)C>[C:12]([C:16]1[Se:20][C:19]([C:21]([NH2:23])=[O:22])=[C:18]([NH:24][C:2]2[C:3]3[CH:11]=[CH:10][CH:9]=[N:8][C:4]=3[N:5]=[CH:6][N:7]=2)[CH:17]=1)([CH3:15])([CH3:13])[CH3:14]

Participants

4

Reactant 2

HCID 5690394-Chloropyrido[2,3-d]pyrimidineHCID 866468893-Amino-5-tert-butylselenophene-2-carboxamide

Product 1

HCID 866982745-tert-Butyl-3-(pyridino[2,3-d]pyrimidin-4-ylamino)selenophene-2-carboxamide

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

As shown in scheme G, 4-chloropyrido[2,3-d]pyrimidine (Robins, R. K. et. al., J. Am. Chem. Soc., 1955, 77, 2256-2260) is reacted with 5-tert-butyl-3-aminoselenophene-2-carboxamide in a protic solvent such as isopropyl alcohol to yield 5-(tert-butyl)-3-(pyridino[3,2-e]pyrimidin-4-ylamino)selenophene-2-carboxamide.

Sources & evidence

ORD record
ord-4219537690a0490f8c6a6709a296dbd8
Source dataset
uspto-grants-2014_08
Patent number
US08815879B2

Reaction notes

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