HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide dimethyl acetal → HCID 86698275, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Reactant | 2-amino-4,5-dimethyl-1H-pyrrole-3-carbonitrile | HCID 2756391 | — |
| Reactant | Acetic acid toluene | HCID 18331056 | — |
| Reactant | HCID 59547213 | HCID 59547213 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 86698275 | HCID 86698275 | — |
Reaction Steps
As shown in scheme K, 2-amino-4,5-dimethyl-1H-pyrrole-3-carbonitrile (Fischer, R. W. et. al., Org. Proc. Res. Dev., 2001, 5, 581-586) is reacted with N,N-dimethylformamide-dimethylacetal in the presence of toluene/acetic acid, followed by methyl 4-amino-5-methylselenophene-2-carboxylate in acetic acid to yield methyl 4-(5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-5-methylselenophene-2-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815879B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-3bd509d34a6249b9bf8cd5f0542fc13e |
| Source note | uspto-grants-2014_08 |