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HRID2408945

反应详情

EQUATION

反应方程式

HRID 2408945 的结构方程式

REACTANTS

反应物

4
结构：COC(OC)N(C)C
HCID78373

Methanamine, 1,1-dimethoxy-N,N-dimethyl-

C5H13NO2

结构：Cc1[nH]c(N)c(C#N)c1C
HCID2756391

2-amino-4,5-dimethyl-1H-pyrrole-3-carbonitrile

C7H9N3

结构：CC(=O)O.Cc1ccccc1
HCID18331056

未命名化合物

结构：COC(=O)c1cc(N)c(C)[se]1
HCID59547213

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)c1cc(Nc2ncnc3[nH]c(C)c(C)c23)c(C)[se]1
HCID86698275

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(=O)O
溶剂HCID176

Acetic Acid

C2H4O2

PROCEDURE

实验过程

As shown in scheme K, 2-amino-4,5-dimethyl-1H-pyrrole-3-carbonitrile (Fischer, R. W. et. al., Org. Proc. Res. Dev., 2001, 5, 581-586) is reacted with N,N-dimethylformamide-dimethylacetal in the presence of toluene/acetic acid, followed by methyl 4-amino-5-methylselenophene-2-carboxylate in acetic acid to yield methyl 4-(5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-5-methylselenophene-2-carboxylate.