Dimethylformamide dimethyl acetal → HCID 86698275, compound

HRID 2408980Notes

Reaction equation

HRID 2408980 reaction equation
[NH2:1][C:2]1[NH:3][C:4]([CH3:10])=[C:5]([CH3:9])[C:6]=1[C:7]#[N:8].[CH3:11]OC(OC)N(C)C.[NH2:19][C:20]1[CH:21]=[C:22]([C:26]([O:28][CH3:29])=[O:27])[Se:23][C:24]=1[CH3:25]>>[CH3:9][C:5]1[C:6]2[C:7]([NH:19][C:20]3[CH:21]=[C:22]([C:26]([O:28][CH3:29])=[O:27])[Se:23][C:24]=3[CH3:25])=[N:8][CH:11]=[N:1][C:2]=2[NH:3][C:4]=1[CH3:10]

Participants

4

Reactant 3

HCID 78373Dimethylformamide dimethyl acetalHCID 27563912-amino-4,5-dimethyl-1H-pyrrole-3-carbonitrileHCID 59547213HCID 59547213, compound

Product 1

HCID 86698275HCID 86698275, compound

Procedure

The reaction of 2-amino-4,5-dimethyl-1H-pyrrole-3-carbonitrile with dimethylformamide-dimethylacetal and methyl 4-amino-5-methylselenophene-2-carboxylate as described in the example 10, gave title compound as a pale brown color solid, mp 238-240° C. 1H NMR (400 MHz, CDCl3): δ 8.74 (1H, br s, exchangeable with D2O), 7.95 (1H, s), 7.37 (1H, s), 3.86 (3H, s), 2.43 (3H, s), 2.32 (3H, s), 2.25 (3H, s); LC-MS (positive ion mode): m/z 363, 365 (M+H)+.

Sources & evidence

ORD record
ord-02af809f9ae44a4ead772ba6dcb43813
Source dataset
uspto-grants-2014_08
Patent number
US08815879B2

Reaction notes

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