Phosphorus oxychloride → HCID 86698298, compound

HRID 2408983Notes

Reaction equation

HRID 2408983 reaction equation
[CH2:1]([C:3]1[C:11]2[C:10](=O)[NH:9][CH:8]=[N:7][C:6]=2[Se:5][C:4]=1[CH3:13])[CH3:2].P(Cl)(Cl)([Cl:16])=O>>[Cl:16][C:10]1[C:11]2[C:3]([CH2:1][CH3:2])=[C:4]([CH3:13])[Se:5][C:6]=2[N:7]=[CH:8][N:9]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 86698299HCID 86698299, compound

Product 1

HCID 86698298HCID 86698298, compoundYield 81%

Procedure

A mixture of 5-ethyl-6-methylselenopheno[2,3-d]pyrimidin-4(3H)-one (300 mg) and phosphorous oxychloride (5 mL) was refluxed for 1 h. The reaction mixture was attained to rt and poured into ice cold water and stirred for 10 min. The precipitated solid was filtered, washed with water and dried to give the product as a brown color solid (260 mg, 81%), mp 58-60° C. 1H NMR (400 MHz, CDCl3): δ 8.68 (1H, s), 3.06 (2H, q, J=7.5 Hz), 2.62 (3H, s), 1.23 (3H, t, J=7.4 Hz).

Workup

  1. temperaturewas refluxed for 1 h
  2. customwas attained to rt
  3. additionpoured into ice cold water
  4. filtrationThe precipitated solid was filtered
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-c0258d0f0f3c4b41a1dcaaf8f541278e
Source dataset
uspto-grants-2014_08
Patent number
US08815879B2

Reaction notes

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