HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2409080Generated: October 29, 2026
N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-(1-(3-(4-methoxybenzyl)-3H-imidazo[4,5-c]pyridin-6-yl)ethyl)pyrimidine-2,4-diamine → N2-(1-(3H-imidazo[4,5-c]pyridin-6-yl)ethyl)-N4-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
https://huagongshe.com/reaction/2409080
Participants
| Role | Name | HCID | Charge |
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| Reactant | N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-(1-(3-(4-methoxybenzyl)-3H-imidazo[4,5-c]pyridin-6-yl)ethyl)pyrimidine-2,4-diamine | HCID 86689878 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | N2-(1-(3H-imidazo[4,5-c]pyridin-6-yl)ethyl)-N4-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine | HCID 78132842 | 46.1% |
Reaction Steps
A mixture of N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-(1-(3-(4-methoxybenzyl)-3H-imidazo[4,5-c]pyridin-6-yl)ethyl)pyrimidine-2,4-diamine (130 mg, 0.27 mmol) in TFA (3 mL) was heated at 70° C. for 2 h. The reaction mixture was concentrated under reduced pressure. The residue was purified by reverse phase preparative HPLC to afford 45 mg (46%) of N2-(1-(3H-imidazo[4,5-c]pyridin-6-yl)ethyl)-N4-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine as white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08815877B2 |
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| Source dataset | uspto-grants-2014_08 |
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| ORD ID | ord-d6ad5b0c811545d2ae897f51ae7018f0 |
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| Source note | uspto-grants-2014_08 |
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