反应详情

温度

70 °C

A mixture of N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-(1-(3-(4-methoxybenzyl)-3H-imidazo[4,5-c]pyridin-6-yl)ethyl)pyrimidine-2,4-diamine (130 mg, 0.27 mmol) in TFA (3 mL) was heated at 70° C. for 2 h. The reaction mixture was concentrated under reduced pressure. The residue was purified by reverse phase preparative HPLC to afford 45 mg (46%) of N2-(1-(3H-imidazo[4,5-c]pyridin-6-yl)ethyl)-N4-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine as white solid.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. customThe residue was purified by reverse phase preparative HPLC