反应详情

温度

90 °C

To a solution of 5-chloro-4-nitro-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole (0.4 g, 2 mmol) in ethanol (10 mL) was added ammonium chloride (0.3 g, 5 mmol) and iron (0.3 g). The reaction was stirred at 90° C. for 30 minutes before filtered through celite and concentrated. The residue was triturated in EtOAc and filtered. The filtrated was concentrated to give the title compound (0.34 g, quant.)

1. filtrationbefore filtered through celite
2. concentrationconcentrated
3. customThe residue was triturated in EtOAc
4. filtrationfiltered
5. concentrationThe filtrated was concentrated