HCID 69093467, compound → HCID 69082882, compound

HRID 2409103Notes

Reaction equation

HRID 2409103 reaction equation
[CH3:1][C:2]([N:7]1[CH:11]=[C:10]([N+:12]([O-])=O)[C:9]([CH3:15])=[N:8]1)([CH3:6])[C:3]([NH2:5])=[O:4].[H][H]>CO.[Pd]>[NH2:12][C:10]1[C:9]([CH3:15])=[N:8][N:7]([C:2]([CH3:1])([CH3:6])[C:3]([NH2:5])=[O:4])[CH:11]=1

Participants

5

Reactant 2

HCID 69093467HCID 69093467, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 69082882HCID 69082882, compoundYield 93.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 2-methyl-2-(3-methyl-4-nitro-1H-pyrazol-1-yl)propanamide (2.5 g, 11.7 mmol) in MeOH (50 mL) was added Pd/C (1 g), exchanged with nitrogen for three times then with hydrogen, and the reaction was stirred at hydrogen atmosphere (1 atm) for 1 h at ambient temperature. The solution was filtered and the filtrate was concentrated under reduced pressure to give crude 2-(4-amino-3-methyl-1H-pyrazol-1-yl)-2-methylpropanamide (2.0 g, 93%) which was used in the next step without further purification.

Workup

  1. filtrationThe solution was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-b82d28b0935f43a2948cf8c020c3d82f
Source dataset
uspto-grants-2014_08
Patent number
US08815882B2

Reaction notes

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