HCID 69093467, compound → HCID 69082882, compound

Participants

Reaction Steps

To a solution of 2-methyl-2-(3-methyl-4-nitro-1H-pyrazol-1-yl)propanamide (2.5 g, 11.7 mmol) in MeOH (50 mL) was added Pd/C (1 g), exchanged with nitrogen for three times then with hydrogen, and the reaction was stirred at hydrogen atmosphere (1 atm) for 1 h at ambient temperature. The solution was filtered and the filtrate was concentrated under reduced pressure to give crude 2-(4-amino-3-methyl-1H-pyrazol-1-yl)-2-methylpropanamide (2.0 g, 93%) which was used in the next step without further purification.

Provenance & Evidence