54639-78-0 → HCID 57497052, compound

HRID 2409208Notes

Reaction equation

HRID 2409208 reaction equation
[NH2:1][C:2]1[N:7]([CH3:8])[C:6](=[O:9])[C:5]([CH3:11])([CH3:10])[C@:4]([C:13]2[CH:18]=[C:17]([NH2:19])[CH:16]=[CH:15][C:14]=2[F:20])([CH3:12])[N:3]=1.[OH:21][CH:22]1[CH2:26][C:25]([CH3:28])([CH3:27])[CH2:24][C:23]1=O.[B][B][B][B][B][B][B][B][B][B]>>[NH2:1][C:2]1[N:7]([CH3:8])[C:6](=[O:9])[C:5]([CH3:10])([CH3:11])[C@:4]([C:13]2[CH:18]=[C:17]([NH:19][CH:23]3[CH2:24][C:25]([CH3:28])([CH3:27])[CH2:26][CH:22]3[OH:21])[CH:16]=[CH:15][C:14]=2[F:20])([CH3:12])[N:3]=1

Participants

4

Reactant 3

HCID 1253096854639-78-0HCID 57497157(S)-2-amino-6-(5-amino-2-fluoro-phenyl)-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one2×HCID 178419135HCID 178419135, compound

Product 1

HCID 57497052HCID 57497052, compound

Procedure

The reductive amination of (S)-2-amino-6-(5-amino-2-fluoro-phenyl)-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one (intermediate J) and rac-2-hydroxy-4,4-dimethyl-cyclopentanone using decaborane yielded a mixture of epimers of the title compound as white solid. MS (ESI): m/z=391.4 [M+H]+.

Workup

  1. customyielded

Sources & evidence

ORD record
ord-97832c953c114ecca9c455463fe470e9
Source dataset
uspto-grants-2014_08
Patent number
US08815881B2

Reaction notes

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