4-(4-Fluoro-phenyl)-piperidine hydrochloride → HCID 53377694, compound

HRID 2409275Notes

Reaction equation

HRID 2409275 reaction equation
[CH:1]1([NH:4][S:5]([C:8]2[CH:9]=[N:10][N:11]3[C:16]([NH:17][C:18]4[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:19]=4[CH3:25])=[C:15]([C:26](OCC)=[O:27])[CH:14]=[N:13][C:12]=23)(=[O:7])=[O:6])[CH2:3][CH2:2]1.Cl.[F:32][C:33]1[CH:38]=[CH:37][C:36]([CH:39]2[CH2:44][CH2:43][NH:42][CH2:41][CH2:40]2)=[CH:35][CH:34]=1>>[CH:1]1([NH:4][S:5]([C:8]2[CH:9]=[N:10][N:11]3[C:16]([NH:17][C:18]4[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:19]=4[CH3:25])=[C:15]([C:26]([N:42]4[CH2:43][CH2:44][CH:39]([C:36]5[CH:35]=[CH:34][C:33]([F:32])=[CH:38][CH:37]=5)[CH2:40][CH2:41]4)=[O:27])[CH:14]=[N:13][C:12]=23)(=[O:7])=[O:6])[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 218981684-(4-Fluoro-phenyl)-piperidine hydrochlorideHCID 71178961HCID 71178961, compound

Product 1

HCID 53377694HCID 53377694, compoundYield 14.9%

Procedure

Using ethyl 3-(N-cyclopropylsulfamoyl)-7-(4-fluoro-2-methylphenylamino)-pyrazolo[1,5-a]pyrimidine-6-carboxylate (0.496 g, 1.145 mmol) obtained in step 1 and 4-(4-fluorophenyl)piperidine hydrochloride (0.072 g, 0.335 mmol) instead of 4-phenylpiperidine, and in the same manner as in Example 1 step 4, the title compound (0.0283 g, 3%) was obtained.

Sources & evidence

ORD record
ord-7ed72e8ec4f249748b1c7bc59e905626
Source dataset
uspto-grants-2014_08
Patent number
US08815874B2

Reaction notes

Loading…