2-Methoxyethylamine → HCID 71178962, compound

HRID 2409280Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]1[N:14]2[N:15]=[CH:16][C:17]([S:18]([OH:21])(=O)=[O:19])=[C:13]2[N:12]=[CH:11][C:10]=1[C:22]([O:24][CH2:25][CH3:26])=[O:23].[CH3:27][O:28][CH2:29][CH2:30][NH2:31]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]1[N:14]2[N:15]=[CH:16][C:17]([S:18](=[O:21])(=[O:19])[NH:31][CH2:30][CH2:29][O:28][CH3:27])=[C:13]2[N:12]=[CH:11][C:10]=1[C:22]([O:24][CH2:25][CH3:26])=[O:23]

Participants

Reactant 2

HCID 80182-Methoxyethylamine

HCID 86681883HCID 86681883, compound

Product 1

HCID 71178962HCID 71178962, compoundYield 100.3%

Procedure

Using 7-(2-chlorophenylamino)-6-(ethoxycarbonyl)pyrazolo[1,5-a]pyrimidine-3-sulfonic acid (0.400 g, 1.008 mmol) obtained in Example 6 step 2 and 2-methoxyethylamine (0.303 g, 4.032 mmol) instead of tert-butylamine, and in the same manner as in Example 1 step 3, the title compound (0.459 g, 100%) was obtained.

Sources & evidence

ORD record: ord-7429033d36ff4042ac1d354b83bfb759
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08815874B2

Reaction notes

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