4-(4-Fluorophenyl)piperidine → HCID 71178899, compound

HRID 2409281Notes

Reaction equation

HRID 2409281 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]1[N:14]2[N:15]=[CH:16][C:17]([S:18](=[O:25])(=[O:24])[NH:19][CH2:20][CH2:21][O:22][CH3:23])=[C:13]2[N:12]=[CH:11][C:10]=1[C:26]([O:28]CC)=O.[F:31][C:32]1[CH:37]=[CH:36][C:35]([CH:38]2[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]2)=[CH:34][CH:33]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]1[N:14]2[N:15]=[CH:16][C:17]([S:18]([NH:19][CH2:20][CH2:21][O:22][CH3:23])(=[O:24])=[O:25])=[C:13]2[N:12]=[CH:11][C:10]=1[C:26]([N:41]1[CH2:42][CH2:43][CH:38]([C:35]2[CH:34]=[CH:33][C:32]([F:31])=[CH:37][CH:36]=2)[CH2:39][CH2:40]1)=[O:28]

Participants

3

Reactant 2

HCID 27591364-(4-Fluorophenyl)piperidineHCID 71178962HCID 71178962, compound

Product 1

HCID 71178899HCID 71178899, compoundYield 16.6%

Procedure

Using ethyl 7-(2-chlorophenylamino)-3-[N-(2-methoxyethyl)sulfamoyl]pyrazolo[1,5-a]pyrimidine-6-carboxylate (0.459 g, 1.008 mmol) obtained in step 1 and 4-(4-fluorophenyl)piperidine (0.158 g, 0.881 mmol) instead of 4-phenylpiperidine, and in the same manner as in Example 1 step 4, the title compound (0.086 g, 15%) was obtained.

Sources & evidence

ORD record
ord-b9a00d44b49e4f0d92bad3dd9668e3db
Source dataset
uspto-grants-2014_08
Patent number
US08815874B2

Reaction notes

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