2,5-Dichloroaniline → HCID 71179006, compound

HRID 2409300Notes

Reaction equation

HRID 2409300 reaction equation
O[C:2]1[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=[CH:4][C:3]=1[C:11]([O:13][CH2:14][CH3:15])=[O:12].[Cl:16][C:17]1[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:18]=1[NH2:19]>>[Cl:16][C:17]1[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:18]=1[NH:19][C:2]1[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=[CH:4][C:3]=1[C:11]([O:13][CH2:14][CH3:15])=[O:12]

Participants

3

Reactant 2

HCID 72622,5-DichloroanilineHCID 178469627HCID 178469627, compound

Product 1

HCID 71179006HCID 71179006, compoundYield 75.5%

Procedure

Using ethyl 7-hydroxypyrazolo[1,5-a]pyrimidine-6-carboxylate (7.50 g, 36.2 mmol) and 2,5-dichloroaniline (5.30 g, 32.6 mmol) instead of 4-fluoro-2-methylaniline, and in the same manner as in Example 1 step 1, the title compound (8.64 g, 68%) was obtained.

Sources & evidence

ORD record
ord-de32a61486da4cfd8782ba45d1880446
Source dataset
uspto-grants-2014_08
Patent number
US08815874B2

Reaction notes

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