Benzenamine, 2-chloro-5-(trifluoromethyl)- → HCID 71178909, compound

HRID 2409309Notes

Reaction equation

HRID 2409309 reaction equation
O[C:2]1[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=[CH:4][C:3]=1[C:11]([O:13][CH2:14][CH3:15])=[O:12].[Cl:16][C:17]1[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][C:18]=1[NH2:19]>>[Cl:16][C:17]1[CH:23]=[CH:22][C:21]([C:24]([F:26])([F:27])[F:25])=[CH:20][C:18]=1[NH:19][C:2]1[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=[CH:4][C:3]=1[C:11]([O:13][CH2:14][CH3:15])=[O:12]

Participants

3

Reactant 2

HCID 8475Benzenamine, 2-chloro-5-(trifluoromethyl)-HCID 178469627HCID 178469627, compound

Product 1

HCID 71178909HCID 71178909, compoundYield 77.7%

Procedure

Using ethyl 7-hydroxypyrazolo[1,5-a]pyrimidine-6-carboxylate (5.0 g, 24.1 mmol) and 2-chloro-5-trifluoromethylaniline (4.25 g, 21.7 mmol) instead of 4-fluoro-2-methylaniline, and in the same manner as in Example 1 step 1, the title compound (6.49 g, 70%) was obtained.

Sources & evidence

ORD record
ord-ae2d8919e3c440659da5c9d1dcac80a6
Source dataset
uspto-grants-2014_08
Patent number
US08815874B2

Reaction notes

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