2,5-Difluoroaniline → HCID 71178882, compound

HRID 2409321Notes

Reaction equation

HRID 2409321 reaction equation
O[C:2]1[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=[CH:4][C:3]=1[C:11]([O:13][CH2:14][CH3:15])=[O:12].[F:16][C:17]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:18]=1[NH2:19]>>[F:16][C:17]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:18]=1[NH:19][C:2]1[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=[CH:4][C:3]=1[C:11]([O:13][CH2:14][CH3:15])=[O:12]

Participants

3

Reactant 2

HCID 677752,5-DifluoroanilineHCID 178469627HCID 178469627, compound

Product 1

HCID 71178882HCID 71178882, compoundYield 62.2%

Procedure

Using ethyl 7-hydroxypyrazolo[1,5-a]pyrimidine-6-carboxylate (2.0 g, 9.65 mmol) and 2,5-difluoroaniline (1.12 g, 8.69 mmol) instead of 4-fluoro-2-methylaniline, and in the same manner as in Example 1 step 1, the title compound (1.72 g, 56%) was obtained.

Sources & evidence

ORD record
ord-9a54a134f9714e75807145d53d35eeb8
Source dataset
uspto-grants-2014_08
Patent number
US08815874B2

Reaction notes

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