3,4-Dichloroaniline → HCID 71179069, compound

HRID 2409329Notes

Reaction equation

HRID 2409329 reaction equation
O[C:2]1[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=[CH:4][C:3]=1[C:11]([O:13][CH2:14][CH3:15])=[O:12].[Cl:16][C:17]1[CH:18]=[C:19]([CH:21]=[CH:22][C:23]=1[Cl:24])[NH2:20]>>[Cl:16][C:17]1[CH:18]=[C:19]([NH:20][C:2]2[N:7]3[N:8]=[CH:9][CH:10]=[C:6]3[N:5]=[CH:4][C:3]=2[C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:21]=[CH:22][C:23]=1[Cl:24]

Participants

3

Reactant 2

HCID 72573,4-DichloroanilineHCID 178469627HCID 178469627, compound

Product 1

HCID 71179069HCID 71179069, compoundYield 71.2%

Procedure

Using ethyl 7-hydroxypyrazolo[1,5-a]pyrimidine-6-carboxylate (3.0 g, 14.5 mmol) and 3,4-dichloroaniline (1.88 g, 11.6 mmol) instead of 4-fluoro-2-methylaniline, and in the same manner as in Example 1 step 1, the title compound (2.90 g, 57%) was obtained.

Sources & evidence

ORD record
ord-3db03c3c1b8549b4a812359579b419ed
Source dataset
uspto-grants-2014_08
Patent number
US08815874B2

Reaction notes

Loading…