反应详情

The compound (57.8 mg, 0.251 mmol) prepared in step 5 was dissolved in 1,4-dioxane (1 ml), added with 3.6N hydrochloric acid 1,4-dioxane solution (1 ml) and then stirred for 24 hours. Once the reaction was completed, the solvent was removed under reduced pressure and accordingly obtained residue was stirred for 30 minutes in ethyl acetate/diethyl ether. The resultant solid was filtered and washed with diethyl ether to obtain the title compound (38.1 mg, yield: 56.9%, green solid).

1. customthe solvent was removed under reduced pressure and accordingly obtained residue
2. stirringwas stirred for 30 minutes in ethyl acetate/diethyl ether
3. filtrationThe resultant solid was filtered
4. washwashed with diethyl ether