1,4-Dioxane hydrochloride → HCID 67381151, compound

Participants

Reaction Steps

The compound (57.8 mg, 0.251 mmol) prepared in step 5 was dissolved in 1,4-dioxane (1 ml), added with 3.6N hydrochloric acid 1,4-dioxane solution (1 ml) and then stirred for 24 hours. Once the reaction was completed, the solvent was removed under reduced pressure and accordingly obtained residue was stirred for 30 minutes in ethyl acetate/diethyl ether. The resultant solid was filtered and washed with diethyl ether to obtain the title compound (38.1 mg, yield: 56.9%, green solid).

Provenance & Evidence