1,4-Dioxane hydrochloride → HCID 67381180, compound

HRID 2409399Notes

Reaction equation

HRID 2409399 reaction equation
[O:1]=[C:2]1[NH:11][C:10]2[CH:12]=[CH:13][C:14]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:15][C:9]=2[C:8]2[NH:7][CH2:6][CH2:5][CH2:4][C:3]1=2.O1CCOCC1.[ClH:27]>O1CCOCC1>[ClH:27].[O:1]=[C:2]1[NH:11][C:10]2[CH:12]=[CH:13][C:14]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:15][C:9]=2[C:8]2[NH:7][CH2:6][CH2:5][CH2:4][C:3]1=2

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 58424883HCID 58424883, compound

Product 1

HCID 67381180HCID 67381180, compoundYield 25%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The compound (7.5 mg, 0.027 mmol) prepared in step 4 was dissolved in 1,4-dioxane (1 ml), added with 3.7 N hydrochloric acid 1,4-dioxane solution (1 ml), and then stirred for 18 hours at room temperature. Once the reaction was completed, generated solid was filtered, washed with ethyl acetate, and dried in vacuo to obtain the title compound (4.5 mg, yield: 25%, white solid).

Workup

  1. filtrationwas filtered
  2. washwashed with ethyl acetate
  3. customdried in vacuo

Sources & evidence

ORD record
ord-528f94596e1649e8aa1e225bae15fce5
Source dataset
uspto-grants-2014_08
Patent number
US08815891B2

Reaction notes

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