Boron tribromide dichloromethane → HCID 58424936, compound

HRID 2409402Notes

Reaction equation

HRID 2409402 reaction equation
C[O:2][C:3]1[CH:17]=[CH:16][C:6]2[NH:7][C:8](=[O:15])[C:9]3[CH:10]=[CH:11][CH:12]=[N:13][C:14]=3[C:5]=2[CH:4]=1.ClCCl.B(Br)(Br)Br>ClCCl>[OH:2][C:3]1[CH:17]=[CH:16][C:6]2[NH:7][C:8](=[O:15])[C:9]3[CH:10]=[CH:11][CH:12]=[N:13][C:14]=3[C:5]=2[CH:4]=1

Participants

4

Reactant 2

HCID 22277759Boron tribromide dichloromethaneHCID 58424967HCID 58424967, compound

Product 1

HCID 58424936HCID 58424936, compoundYield 70.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The compound (190 mg, 0.84 mmol) prepared in step 1 was dissolved in dichloromethane (2 ml), added with 1 M boron tribromide dichloromethane solution (4.2 ml). The mixture was stirred overnight at room temperature. The reaction mixture was poured into ice water and the precipitate was collected by filteration to obtain the title compound (125 mg, yield: 70%, yellow solid).

Workup

  1. customthe precipitate was collected by filteration

Sources & evidence

ORD record
ord-d84ee9f7b4c944d09afc5130c7318a7a
Source dataset
uspto-grants-2014_08
Patent number
US08815891B2

Reaction notes

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