1,4-Dioxane hydrochloride → HCID 58424971, compound

HRID 2409404Notes

Reaction equation

HRID 2409404 reaction equation
[O:1]=[C:2]1[NH:11][C:10]2[CH:12]=[CH:13][C:14]([O:16][CH:17]3[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]3)=[CH:15][C:9]=2[C:8]2[N:7]=[CH:6][CH:5]=[CH:4][C:3]1=2.O1CCOCC1.Cl>O1CCOCC1>[NH:20]1[CH2:19][CH2:18][CH:17]([O:16][C:14]2[CH:13]=[CH:12][C:10]3[NH:11][C:2](=[O:1])[C:3]4[CH:4]=[CH:5][CH:6]=[N:7][C:8]=4[C:9]=3[CH:15]=2)[CH2:22][CH2:21]1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 58424876HCID 58424876, compound

Product 1

HCID 58424971HCID 58424971, compoundYield 108.8%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The compound (110 mg, 0.28 mmol) prepared in step 3 was dissolved in 1,4-dioxane, added with 3.7 N hydrochloric acid 1,4-dioxane solution. The resulting mixture was stirred overnight at room temperature and the precipitate was collected by filtration to obtain the title compound (90 mg, yield: 98%, yellow solid).

Workup

  1. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-83092cc34e9247f880f8293303accdfb
Source dataset
uspto-grants-2014_08
Patent number
US08815891B2

Reaction notes

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