1,4-Dioxane hydrochloride → HCID 67381269, compound

HRID 2409411Notes

Reaction equation

HRID 2409411 reaction equation
[CH3:1][N:2]1[C:11]2[C:10]3[CH:12]=[C:13]([O:16][CH:17]4[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH2:18]4)[CH:14]=[CH:15][C:9]=3[NH:8][C:7](=[O:24])[C:6]=2[CH2:5][CH2:4][CH2:3]1.O1CCOCC1.[ClH:31]>O1CCOCC1>[ClH:31].[ClH:31].[CH3:1][N:2]1[C:11]2[C:10]3[CH:12]=[C:13]([O:16][CH:17]4[CH2:18][CH2:19][N:20]([CH3:23])[CH2:21][CH2:22]4)[CH:14]=[CH:15][C:9]=3[NH:8][C:7](=[O:24])[C:6]=2[CH2:5][CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 58424850HCID 58424850, compound

Product 1

HCID 67381269HCID 67381269, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The compound (25 mg, 0.08 mmol) prepared in step 1 was dissolved in 1,4-dioxane (3 ml), added with 3.7 N hydrochloric acid 1,4-dioxane solution. The resulting mixture was stirred for 3 days at room temperature and the precipitate was collected by filtration to obtain the title compound (524 mg, yield: 79%, yellow solid).

Workup

  1. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-b9608b457aff449fa6735cc95b2d4f37
Source dataset
uspto-grants-2014_08
Patent number
US08815891B2

Reaction notes

Loading…