1,4-Dioxane hydrochloride → HCID 58424899, compound

HRID 2409414Notes

Reaction equation

HRID 2409414 reaction equation
C(=O)([O:7][C:8]1[CH:25]=[CH:24][C:11]2[N:12]([CH2:21][O:22][CH3:23])[C:13](=[O:20])[C:14]3[CH:15]=[CH:16][CH:17]=[N:18][C:19]=3[C:10]=2[CH:9]=1)OC(C)(C)C.O1CCOCC1.Cl>O1CCOCC1>[OH:7][C:8]1[CH:25]=[CH:24][C:11]2[N:12]([CH2:21][O:22][CH3:23])[C:13](=[O:20])[C:14]3[CH:15]=[CH:16][CH:17]=[N:18][C:19]=3[C:10]=2[CH:9]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 58424947HCID 58424947, compound

Product 1

HCID 58424899HCID 58424899, compoundYield 98.3%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The compound (580 mg, 1.627 mmol) prepared in step 4 was dissolved in 1,4-dioxane (10 ml), added with 3.7 N hydrochloric acid 1,4-dioxane solution (6 ml). The resulting mixture was stirred for one day at room temperature and the precipitate was collected by filtration to obtain the title compound (410 mg, yield: 98%, yellow solid).

Workup

  1. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-af727358b3dd4ae281f56978880208a7
Source dataset
uspto-grants-2014_08
Patent number
US08815891B2

Reaction notes

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