Hydrochloric Acid → HCID 67381337, compound

Participants

Reaction Conditions

Reaction Steps

8-ethyl-6-(methoxymethyl)-1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridine-5(6H)-one (130 mg, 0.48 mmol) prepared in step 5 of Example 38 was dissolved in ethanol (8 ml) and added with conc. hydrochloric acid solution (2.5 ml). The mixture was stirred overnight at 80° C. and the precipitate was collected by filteration to obtain the title compound (120 mg, yield: 95%, yellow solid).

Provenance & Evidence