Hydrochloric Acid → HCID 67381337, compound

HRID 2409442Notes

Reaction equation

HRID 2409442 reaction equation
[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]2[C:15]3[NH:14][CH2:13][CH2:12][CH2:11][C:10]=3[C:9](=[O:16])[N:8](COC)[C:7]=2[CH:20]=1)[CH3:2].[ClH:21]>C(O)C>[ClH:21].[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]2[C:15]3[NH:14][CH2:13][CH2:12][CH2:11][C:10]=3[C:9](=[O:16])[NH:8][C:7]=2[CH:20]=1)[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58424840HCID 58424840, compound

Product 1

HCID 67381337HCID 67381337, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

8-ethyl-6-(methoxymethyl)-1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridine-5(6H)-one (130 mg, 0.48 mmol) prepared in step 5 of Example 38 was dissolved in ethanol (8 ml) and added with conc. hydrochloric acid solution (2.5 ml). The mixture was stirred overnight at 80° C. and the precipitate was collected by filteration to obtain the title compound (120 mg, yield: 95%, yellow solid).

Workup

  1. customthe precipitate was collected by filteration

Sources & evidence

ORD record
ord-816155515d334ee3b18513b1e1c6dfd2
Source dataset
uspto-grants-2014_08
Patent number
US08815891B2

Reaction notes

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