Hydrochloric Acid → HCID 67381193, compound

HRID 2409444Notes

Reaction equation

HRID 2409444 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[CH:6]=[CH:7][C:8]2[C:17]3[NH:16][CH2:15][CH2:14][CH2:13][C:12]=3[C:11](=[O:18])[N:10](COC)[C:9]=2[CH:22]=1)[CH3:3].[ClH:23]>C(O)C>[ClH:23].[ClH:23].[CH3:3][N:2]([CH2:4][C:5]1[CH:6]=[CH:7][C:8]2[C:17]3[NH:16][CH2:15][CH2:14][CH2:13][C:12]=3[C:11](=[O:18])[NH:10][C:9]=2[CH:22]=1)[CH3:1]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58424865HCID 58424865, compound

Product 1

HCID 67381193HCID 67381193, compoundYield 84.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

The compound (57.8 mg, 0.192 mmol) prepared in step 7 was dissolved in ethanol (3 ml), added with 12 N hydrochloric acid aqueous solution (3.0 ml). The resulting mixture was heated to 90° C. and stirred for 3 hours. The mixture was concentrated to dryness and dissolved in ethyl acetate. After stirring for 30 minutes, the precipitate was filtered and washed with diethyl ether to obtain the title compound (53.5 mg, yield: 84.5%, ivory solid).

Workup

  1. concentrationThe mixture was concentrated to dryness
  2. dissolutiondissolved in ethyl acetate
  3. stirringAfter stirring for 30 minutes
  4. filtrationthe precipitate was filtered
  5. washwashed with diethyl ether

Sources & evidence

ORD record
ord-3bd88ac17f164012bb5779770fc08f68
Source dataset
uspto-grants-2014_08
Patent number
US08815891B2

Reaction notes

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