Hydrochloric Acid → HCID 178479655, compound

HRID 2409453Notes

Reaction equation

HRID 2409453 reaction equation
[NH:1]1[C:5]([CH2:6][C:7]2[CH:8]=[CH:9][C:10]3[C:19]4[NH:18][CH2:17][CH2:16][CH2:15][C:14]=4[C:13](=[O:20])[N:12](COC)[C:11]=3[CH:24]=2)=[N:4][N:3]=[N:2]1.[ClH:25]>C(O)C>[ClH:25].[NH:4]1[C:5]([CH2:6][C:7]2[CH:8]=[CH:9][C:10]3[C:19]4[NH:18][CH2:17][CH2:16][CH2:15][C:14]=4[C:13](=[O:20])[NH:12][C:11]=3[CH:24]=2)=[N:1][N:2]=[N:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178496774HCID 178496774, compound

Product 1

HCID 178479655HCID 178479655, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

The compound (34 mg, 0.10 mmol) prepared in step 2 was dissolved in ethanol (5 ml), added with conc. hydrochloric acid (1.0 ml). The resulting mixture was stirred at 80° C. for 10 hours. Once the reaction was completed, the mixture concentrated under reduced pressure and filtered to obtain the title compound (28 mg, yield: 84%, yellow solid).

Workup

  1. concentrationthe mixture concentrated under reduced pressure
  2. filtrationfiltered

Sources & evidence

ORD record
ord-120bdae65dc74002bd0ede99dbf242c1
Source dataset
uspto-grants-2014_08
Patent number
US08815891B2

Reaction notes

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