Hydrochloric Acid → HCID 67381262, compound

HRID 2409456Notes

Reaction equation

HRID 2409456 reaction equation
[CH3:1][O:2][C:3]1[C:16]2[C:15]3[NH:14][CH2:13][CH2:12][CH2:11][C:10]=3[C:9](=[O:17])[N:8](COC)[C:7]=2[CH:6]=[C:5]([CH2:21][NH:22][N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)[CH:4]=1.[ClH:29]>C(O)C>[ClH:29].[ClH:29].[ClH:29].[CH3:1][O:2][C:3]1[C:16]2[C:15]3[NH:14][CH2:13][CH2:12][CH2:11][C:10]=3[C:9](=[O:17])[NH:8][C:7]=2[CH:6]=[C:5]([CH2:21][NH:22][N:23]2[CH2:24][CH2:25][O:26][CH2:27][CH2:28]2)[CH:4]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67381226HCID 67381226, compound

Product 1

HCID 67381262HCID 67381262, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
75 °C

Procedure

The compound (18 mg, 0.046 mmol) prepared in step 3 was dissolved in ethanol (1 ml), and added with 12 N aqueous solution of hydrochloric acid (1.5 ml). The reaction mixture was stirred at 75° C. for 2 hours. The solvent was concentrated under reduced pressure and the residue was dissolved in ethyl acetate. The precipitate was filtered, washed with ethyl acetate, and dried in vacuo to obtain the title compound (20.1 mg, yield: 96%, yellow solid).

Workup

  1. concentrationThe solvent was concentrated under reduced pressure
  2. dissolutionthe residue was dissolved in ethyl acetate
  3. filtrationThe precipitate was filtered
  4. washwashed with ethyl acetate
  5. customdried in vacuo

Sources & evidence

ORD record
ord-63a0bb2eeecf46c0a648a18699b8a46b
Source dataset
uspto-grants-2014_08
Patent number
US08815891B2

Reaction notes

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