Dichloromethane → HCID 58424948, compound

Participants

Reaction Steps

Dichloromethane (60 ml) and methanol (60 ml) were added to 8-(morpholinomethyl)-1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridine-5(6H)-one dihydrochloride (13 g, 31.2 mmol) prepared in Example 49, and then triehylamine (13.05 ml, 93.6 mmol) was added dropwise at room temperature. After stirring at room temperature for 30 minutes, the precipitate was collected by filteration, washed with ethyl acetate (20 ml), and dried in vacuo to obtain the title compound (10 g, yield: 93%, white solid).

Provenance & Evidence