Dichloromethane → HCID 58424948, compound

HRID 2409461Notes

Reaction equation

HRID 2409461 reaction equation
ClCCl.Cl.Cl.[O:6]1[CH2:11][CH2:10][N:9]([CH2:12][C:13]2[CH:14]=[CH:15][C:16]3[C:25]4[NH:24][CH2:23][CH2:22][CH2:21][C:20]=4[C:19](=[O:26])[NH:18][C:17]=3[CH:27]=2)[CH2:8][CH2:7]1.C(N(CC)CC)C>CO>[O:6]1[CH2:7][CH2:8][N:9]([CH2:12][C:13]2[CH:14]=[CH:15][C:16]3[C:25]4[NH:24][CH2:23][CH2:22][CH2:21][C:20]=4[C:19](=[O:26])[NH:18][C:17]=3[CH:27]=2)[CH2:10][CH2:11]1

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 67381277HCID 67381277, compound

Product 1

HCID 58424948HCID 58424948, compoundYield 107.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Dichloromethane (60 ml) and methanol (60 ml) were added to 8-(morpholinomethyl)-1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridine-5(6H)-one dihydrochloride (13 g, 31.2 mmol) prepared in Example 49, and then triehylamine (13.05 ml, 93.6 mmol) was added dropwise at room temperature. After stirring at room temperature for 30 minutes, the precipitate was collected by filteration, washed with ethyl acetate (20 ml), and dried in vacuo to obtain the title compound (10 g, yield: 93%, white solid).

Workup

  1. customthe precipitate was collected by filteration
  2. washwashed with ethyl acetate (20 ml)
  3. customdried in vacuo

Sources & evidence

ORD record
ord-4e44540dc8dc4c928754c27b91a22a2c
Source dataset
uspto-grants-2014_08
Patent number
US08815891B2

Reaction notes

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