HCID 70348174, compound → HCID 68106252, compound

HRID 2409600Notes

Reaction equation

HRID 2409600 reaction equation
C(OC(=O)[NH:10][S:11]([N:14]1[CH2:18][CH2:17][CH:16]([OH:19])[CH2:15]1)(=[O:13])=[O:12])C1C=CC=CC=1>[C].[Pd].CO>[OH:19][CH:16]1[CH2:17][CH2:18][N:14]([S:11]([NH2:10])(=[O:13])=[O:12])[CH2:15]1

Participants

4

Reactant 1

HCID 70348174HCID 70348174, compound

Product 1

HCID 68106252HCID 68106252, compoundYield 99.2%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

Benzyl[(3-hydroxypyrrolidin-1-yl)sulfonyl]carbamate (2.55 g) was added to MeOH, and subsequently, 10% palladium carbon (657 mg, 55% wet) was added thereto, followed by stirring at a normal temperature/a normal pressure for about 3 hours under a hydrogen atmosphere. The catalyst was collected by filtration through Celite, and the filtrate was concentrated under reduced pressure to obtain 3-hydroxypyrrolidin-1-sulfonamide (1.4 g) as a colorless oily substance.

Workup

  1. filtrationThe catalyst was collected by filtration through Celite
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-c205ccf1031f456ebf24e3a6db335a27
Source dataset
uspto-grants-2014_08
Patent number
US08815920B2

Reaction notes

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