Hydrochloric Acid → 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine hydrochloride

HRID 2409625Notes

Reaction equation

HRID 2409625 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][N:15]2[CH2:20][CH2:19][N:18]([CH2:21][CH3:22])[CH2:17][CH2:16]2)=[CH:10][N:9]=1)(C)(C)C.[ClH:24]>O1CCOCC1>[ClH:24].[CH2:21]([N:18]1[CH2:17][CH2:16][N:15]([CH2:14][C:11]2[CH:12]=[CH:13][C:8]([NH2:7])=[N:9][CH:10]=2)[CH2:20][CH2:19]1)[CH3:22]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66914627[5-(4-Ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]carbamic acid tert-butyl ester

Product 1

HCID 669145365-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of [5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-carbamic acid tert-butyl ester (Step 26.2) (0.75 g, 2.8 mmol) and a 4 N solution of HCl in dioxane (20 mL) was stirred for 72 h at rt and concentrated to afford 660 mg of the title compound as a white solid: ESI-MS: 221.1 [M+H]+; tR=0.80 min (System 1).

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-3510da82f0db4bb0989c287988bdc6c8
Source dataset
uspto-grants-2014_08
Patent number
US08815901B2

Reaction notes

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