1,1'-Carbonyldiimidazole → HCID 66673986, compound

HRID 240963Notes

Reaction equation

HRID 240963 reaction equation
[F:1][C:2]1[C:7]([F:8])=[C:6]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:11]=2[I:17])[C:5]([NH2:18])=[C:4]([O:19][CH3:20])[CH:3]=1.[C:21](N1C=CN=C1)(N1C=CN=C1)=[O:22]>C(Cl)Cl>[F:1][C:2]1[CH:3]=[C:4]([O:19][CH3:20])[C:5]2[NH:18][C:21](=[O:22])[N:9]([C:10]3[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:11]=3[I:17])[C:6]=2[C:7]=1[F:8]

Participants

4

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 86618900HCID 86618900, compound

Product 1

HCID 66673986HCID 66673986, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To the stirred solution of 5,6-difluoro-N1-(4-fluoro-2-iodophenyl)-3-methoxybenzene-1,2-diamine (0.17 gm, 0.43 mmol) in CH2Cl2 (2 ml), 1,1′-Carbonyldiimidazole (0.085 gm, 0.53 mmol) was added. This reaction mixture was kept stirring at room temperature for 16 hours when product precipitated out. The white solid was filtered and used further without any purification. (0.089 gm); m/z=419 [M−1]−.

Workup

  1. customprecipitated out
  2. filtrationThe white solid was filtered
  3. customused further without any purification

Sources & evidence

ORD record
ord-dc5984f4a536433795814023b46f1dba
Source dataset
uspto-grants-2014_02
Patent number
US08648116B2

Reaction notes

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