反应详情

温度

80 °C

6-bromo-7-methoxyquinazolin-4(3H)-one (53 mg, 0.21 mmol) was taken into thionyl chloride (1.5 mL) followed by addition of catalytic DMF. The mixture was heated to 80° C. for 2 h then concentrated. The residue was partitioned with ethyl acetate and saturated aqueous sodium bicarbonate. The organic phase was washed with brine then dried over anhydrous sodium sulfate, filtered and concentrated to give 6-bromo-4-chloro-7-methoxyquinazoline (36 mg, 62% yield) as a brown solid. MS (EI) for C9H6BrClN2O: 275 (MH+).

1. concentrationthen concentrated
2. customThe residue was partitioned with ethyl acetate and saturated aqueous sodium bicarbonate
3. washThe organic phase was washed with brine
4. dry with materialthen dried over anhydrous sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated