N-Iodosuccinimide → Methyl 2-amino-5-iodo-4-methoxybenzoate

HRID 240992Notes

Reaction equation

HRID 240992 reaction equation
[I:1]N1C(=O)CCC1=O.[NH2:9][C:10]1[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][C:11]=1[C:12]([O:14][CH3:15])=[O:13]>>[I:1][C:17]1[C:18]([O:20][CH3:21])=[CH:19][C:10]([NH2:9])=[C:11]([CH:16]=1)[C:12]([O:14][CH3:15])=[O:13]

Participants

3

Reactant 2

HCID 120273N-IodosuccinimideHCID 12919999Methyl 2-amino-4-methoxybenzoate

Product 1

HCID 66820461Methyl 2-amino-5-iodo-4-methoxybenzoate

Procedure

Synthesized according to the method of reagent preparation 1 by N-iodosuccinimide iodination of methyl 2-amino-4-methoxybenzoate to give methyl 5-iodo-2-amino-4-methoxybenzoate then proceeding with step 1. 1H NMR (400 MHz, CDCl3): 8.97, (s, 1H), 8.75, 7.31 (s, 1H), 4.08 (s, 3H). GC-MS for C9H6ClIN2O: 319 (M+).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-ddaadf64dc0a43839c37f76439ae3ae0
Source dataset
uspto-grants-2014_02
Patent number
US08648066B2

Reaction notes

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