2-Hydroxy-2-methylpropanimidamide hydrochloride → 2-(4-Chloro-6,6-dimethyl-5,6,7,8-tetrahydroquinazolin-2-yl)propan-2-ol

HRID 241009Notes

Reaction equation

HRID 241009 reaction equation
O[C:2]1[CH2:7][CH2:6][C:5]([CH3:9])([CH3:8])[CH2:4][C:3]=1[C:10]([O-])=O.[ClH:13].[OH:14][C:15]([CH3:20])([CH3:19])[C:16](=[NH:18])[NH2:17]>>[Cl:13][C:10]1[C:3]2[CH2:4][C:5]([CH3:8])([CH3:9])[CH2:6][CH2:7][C:2]=2[N:17]=[C:16]([C:15]([OH:14])([CH3:20])[CH3:19])[N:18]=1

Participants

3

Reactant 2

HCID 426142842-Hydroxy-2-methylpropanimidamide hydrochlorideHCID 178425726HCID 178425726, compound

Product 1

HCID 866478162-(4-Chloro-6,6-dimethyl-5,6,7,8-tetrahydroquinazolin-2-yl)propan-2-ol

Procedure

Synthesized according to the method of reagent preparation 8 using 2-hydroxy-5,5-dimethylcyclohex-1-enecarboxylate and 2-hydroxy-2-methylpropanimidamide hydrochloride in step 2. MS (ES) for C13H19ClN2: 255 (MH+).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-a01ee170ac154412b6f505c1205c9d38
Source dataset
uspto-grants-2014_02
Patent number
US08648066B2

Reaction notes

Loading…