HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloro-2-methylaniline → 2-Bromo-5-[(5-chloro-2-methyl-phenylamino)-(4-cyano-phenyl)-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloro-2-methylaniline | HCID 7260 | — |
| Reactant | 2-bromo-5-[(4-cyano-phenyl)-hydroxy-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester | HCID 86707757 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | 2-Bromo-5-[(5-chloro-2-methyl-phenylamino)-(4-cyano-phenyl)-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester | HCID 86707756 | — |
Reaction Steps
The title compound was prepared in analogy to the procedure described for step E2 using 2-bromo-5-[(4-cyano-phenyl)-hydroxy-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester (step H3) and 5-chloro-2-methyl-aniline as starting materials. tR: 1.35 min (LC-MS 2); ESI-MS: 515.2 [M−H]+ (LC-MS 2); Rf=0.16 (hexane/ EtOAc, 3:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815926B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-fba46484a78d4b4085f68615d79901bd |
| Source note | uspto-grants-2014_08 |